Description

n-2-Propynyl Rasagiline Hydrochloride is a high-purity pharmaceutical intermediate and reference standard. This compound is critical for research and development in the field of neurology and for the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on neurodegenerative diseases.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of rasagiline and related analogs for the treatment of Parkinson's disease.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating monoamine oxidase (MAO) inhibition mechanisms and neuroprotective pathways.
• Process Development: Serves as a critical material for scaling up and optimizing API manufacturing processes under GMP conditions.
• Impurity Profiling: Used to identify, characterize, and quantify related substances in rasagiline mesylate drug substance batches.

Basic Information

Item	Detail
Product Name	n-2-Propynyl Rasagiline Hydrochloride
CAS No.	1458609-07-8
Molecular Formula	C13H17ClN2
Molecular Weight	236.74 g/mol
Synonyms	1H-Inden-1-amine, 2,3-dihydro-N-2-propynyl-, hydrochloride (1:1); (R)-N-2-Propynyl-1-indanamine hydrochloride; (R)-N-Propargyl-1-aminoindane hydrochloride; Rasagiline N-Propargyl Intermediate Hydrochloride; Rasagiline Propynyl Impurity Hydrochloride; (R)-(-)-N-Propargyl-1-aminoindane HCl; 1-Aminoindan Propargyl Derivative Hydrochloride
EINECS	Contact for details

Quality Control

Our n-2-Propynyl Rasagiline Hydrochloride is manufactured and tested to meet stringent quality standards suitable for pharmaceutical R&D. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant guidelines and specifications can be customized to support your specific project requirements, from research grade to GMP.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.