Description

Methyl 4-Bromomethyl-3,5-Difluorobenzoate is a high-value, multi-functional organic building block characterized by its reactive bromomethyl and ester groups on a difluorinated aromatic ring. This compound is essential for facilitating efficient carbon-carbon bond formation and molecular diversification in advanced synthetic pathways. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorobenzene motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials due to its ability to introduce functional handles onto aromatic cores.
• Chemical Biology Probes: Utilized to synthesize molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up campaigns in fine chemical production.

Basic Information

Product Name	Methyl 4-Bromomethyl-3,5-Difluorobenzoate
CAS No.	1446516-72-8
Molecular Formula	C9H7BrF2O2
Molecular Weight	265.05 g/mol
Synonyms	Methyl 4-(Bromomethyl)-3,5-difluorobenzoate; 3,5-Difluoro-4-(bromomethyl)benzoic Acid Methyl Ester; Benzoic acid, 4-(bromomethyl)-3,5-difluoro-, methyl ester; Methyl 3,5-difluoro-4-(bromomethyl)benzoate; 4-Bromomethyl-3,5-difluorobenzoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 4-Bromomethyl-3,5-Difluorobenzoate is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high purity and lot-to-lot consistency to meet the stringent requirements of research and process chemistry. Certificates of Analysis (COA) detailing identity, purity (typically by HPLC/NMR), and impurity profiles are provided with each shipment to ensure full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.