Description

3,5-Bis(Difluoromethoxy)Benzoic Acid is a high-purity, fluorinated benzoic acid derivative of significant interest in advanced organic synthesis. This compound matters as a versatile and valuable building block for creating complex molecules with enhanced properties, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials where the introduction of difluoromethoxy groups can modulate lipophilicity, metabolic stability, and biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used as a precursor in the manufacture of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy moiety can improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a fluorinated aromatic core for constructing advanced electronic materials used in displays and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine-containing functional groups into polymer backbones, enhancing chemical resistance and thermal stability of specialty polymers.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and creating libraries of fluorinated compounds for screening in various applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	3,5-Bis(Difluoromethoxy)Benzoic Acid
CAS No.	1432678-93-7
Molecular Formula	C9H6F4O4
Molecular Weight	254.14 g/mol
Synonyms	3,5-Bis(difluoromethoxy)benzoic acid; Benzoic acid, 3,5-bis(difluoromethoxy)-; 3,5-Difluoromethoxybenzoic Acid (ambiguous); 3,5-Bis(difluoromethoxy)benzenecarboxylic acid; 1432678-93-7; DFMBA; 3,5-BDFMBA
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Difluoromethoxy)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We can supply material tailored to various purity grades, including standard research grade and higher-purity grades suitable for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (HPLC)	≥99.0% (High Purity Grade)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.