Description

2,5-Difluoro-4-(4-Methylpiperazin-1-Yl)Benzoic Acid is a high-value, multi-functional chemical building block featuring a benzoic acid core substituted with fluorine atoms and a methylpiperazine moiety. This compound matters for its role as a critical intermediate in the synthesis of complex, biologically active molecules, offering precise structural control for advanced research and development. It is primarily needed by pharmaceutical, agrochemical, and advanced material scientists engaged in drug discovery, crop protection, and specialty polymer development.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, where the difluoro and piperazine groups contribute to enhanced biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for constructing sophisticated ligands in catalytic systems and metal-organic frameworks (MOFs) for specialized chemical transformations.
• Material Science Research: Employed in the synthesis of monomers for high-performance polymers, liquid crystals, and organic electronic materials due to its rigid aromatic structure and functional handles.
• Chemical Biology Probe: Utilized as a scaffold for developing fluorescent tags, photoaffinity labels, and other molecular probes to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated piperazine derivative.

Basic Information

Item	Details
Product Name	2,5-Difluoro-4-(4-Methylpiperazin-1-Yl)Benzoic Acid
CAS No.	1430223-87-2
Molecular Formula	C12H14F2N2O2
Molecular Weight	256.25 g/mol
Synonyms	2,5-Difluoro-4-(4-methyl-1-piperazinyl)benzoic acid; 4-(4-Methylpiperazin-1-yl)-2,5-difluorobenzoic acid; Benzoic acid, 2,5-difluoro-4-(4-methyl-1-piperazinyl)-; 1430223-87-2; 2,5-Difluoro-4-(4-methylpiperazino)benzoic acid; 2,5-Difluoro-4-(N-methylpiperazino)benzoic acid
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluoro-4-(4-Methylpiperazin-1-Yl)Benzoic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.