Description

2,3,6-Trifluorocinnamic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and agrochemicals, where the introduction of fluorine atoms is crucial for modulating biological activity, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex, value-added molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where fluorination enhances efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Peptidomimetics & Bioisosteres: Employed in medicinal chemistry to create fluorinated analogs of natural products and peptides, improving their drug-like properties.
• Chemical Research & Development: A versatile reagent for academic and industrial research exploring new fluorination methodologies and novel chemical entities.

Basic Information

Product Name	2,3,6-Trifluorocinnamic Acid
CAS No.	1430115-89-1
Molecular Formula	C9H5F3O2
Molecular Weight	202.13 g/mol
Synonyms	(2E)-3-(2,3,6-Trifluorophenyl)prop-2-enoic acid; 2,3,6-Trifluorocinnamic acid, (E)-; trans-2,3,6-Trifluorocinnamic Acid; (E)-3-(2,3,6-Trifluorophenyl)acrylic acid; 2,3,6-Trifluoro-trans-cinnamic Acid; β-(2,3,6-Trifluorophenyl)acrylic Acid
EINECS	Contact for details

Quality Control

Our 2,3,6-Trifluorocinnamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with complete batch data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.