Description

Daptomycin is a potent cyclic lipopeptide antibiotic belonging to the last-resort class of antimicrobial agents. It is critically important for its bactericidal activity against Gram-positive pathogens, including multidrug-resistant strains like MRSA and VRE. This high-purity active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers in the development and production of injectable formulations for serious systemic infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable antibiotic formulations.
• Complicated Skin and Skin Structure Infections (cSSSI): Treatment of severe bacterial infections of the skin and underlying tissues.
• Staphylococcus aureus Bacteremia: Including right-sided infective endocarditis caused by methicillin-susceptible and methicillin-resistant S. aureus (MRSA).
• Research & Development: Used in microbiological research, mechanism of action studies, and development of new combination therapies.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, and microbiological assays.
• Veterinary Pharmaceuticals: Potential application in treating serious bacterial infections in animals.

Basic Information

Item	Details
Product Name	Daptomycin
CAS No.	1429504-48-2
Molecular Formula	C72H101N17O26
Molecular Weight	1620.67 g/mol
Synonyms	Daptomycin; Cubicin; LY 146032; Deptomycin; (3S,6R,9R,12R,15S,18S,21R,24S,27S,30S,33S)-30-[(2R)-2-Aminopentanamido]-33-[(2R,3S)-3-[(1R)-1-hydroxyethyl]oxiran-2-yl]-27-[(1S)-1-hydroxyethyl]-3,6,9,12,15,18,21,24-octaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazatricyclo[28.3.0.04,9]tritriacontane-12-carboxylic acid; Antibiotic LY 146032; Dapcin
EINECS	Contact for details

Quality Control

Our Daptomycin is manufactured under strict quality systems to meet the exacting standards of the pharmaceutical industry. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and potency, identification by spectroscopic methods, and stringent limits for related substances and residual solvents. A Certificate of Analysis (COA) documenting full compliance with specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Bacterial Endotoxins	< 1.0 EU/mg
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.