Description

(+)-Fluorenylethylchloroformate is a chiral derivatization reagent of significant importance in analytical chemistry. Its core value proposition lies in enabling the highly sensitive and selective analysis of chiral compounds, particularly amino acids and amines, via high-performance liquid chromatography (HPLC). This product is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and fine chemical sectors who require precise enantiomeric separation and quantification for drug development and purity assessment.

Application

• Chiral Derivatization for HPLC Analysis: Primary use for pre-column derivatization of chiral amines, amino acids, and other compounds containing amino groups to create diastereomers separable on standard reverse-phase columns.
• Pharmaceutical Research & Development: Critical for determining enantiomeric purity of active pharmaceutical ingredients (APIs) and intermediates during synthesis and process optimization.
• Biomarker Analysis: Used in metabolomics and clinical research for the sensitive detection and quantification of D- and L-amino acids in biological samples.
• Quality Control & Assurance: Employed in QC labs to monitor enantiomeric excess (ee) in fine chemicals and ensure compliance with strict regulatory specifications for chiral drugs.
• Food & Beverage Analysis: Applicable for analyzing amino acids and other chiral components to assess quality, authenticity, and nutritional content.
• Method Development & Validation: A standard reagent for developing and validating robust chiral analytical methods in compliance with ICH guidelines.

Basic Information

Product Name	(+)-Fluorenylethylchloroformate
CAS No.	1428936-75-7
Molecular Formula	C18H15ClO2
Molecular Weight	298.76 g/mol
Synonyms	(+)-FLEC; (S)-(+)-1-(9-Fluorenyl)ethyl chloroformate; (S)-1-(9-Fluorenyl)ethyl Chloroformate; (S)-(+)-1-(9-Fluorenyl)ethyl Chloroformate; (+)-1-(9-Fluorenyl)ethyl Chloroformate; (S)-FLEC; Fmoc-Cl derivative; Chiral FLEC reagent
EINECS	Contact for details

Quality Control

Our (+)-Fluorenylethylchloroformate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for sensitive analytical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Solubility	Soluble in acetonitrile, dichloromethane, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.