Description

Methyl 4-Amino-2-Bromo-3-Fluorobenzoate is a high-purity, multi-functional halogenated benzoate derivative serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring distinct amino, bromo, and fluoro substituents, makes it an invaluable intermediate for constructing complex pharmacophores and agrochemical active ingredients. This compound is primarily sought by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for developing new active compounds and optimizing synthetic routes.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting kinase inhibitors, anti-cancer agents, and other therapeutic small molecules.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, where the halogen and amino groups contribute to biological activity and metabolic stability.
• Material Science Precursor: Serves as a starting material for synthesizing specialized dyes, pigments, and organic electronic materials due to its conjugated aromatic system and functional handles.
• Chemical Research & Development: Employed in academic and industrial labs for methodological studies in cross-coupling reactions, fluorination chemistry, and the development of new synthetic methodologies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes under cGMP conditions where required.

Basic Information

Product Name	Methyl 4-Amino-2-Bromo-3-Fluorobenzoate
CAS No.	1427423-64-0
Molecular Formula	C8H7BrFNO2
Molecular Weight	248.05 g/mol
Synonyms	Benzoic acid, 4-amino-2-bromo-3-fluoro-, methyl ester; Methyl 4-amino-2-bromo-3-fluorobenzoate; 4-Amino-2-bromo-3-fluorobenzoic acid methyl ester; 2-Bromo-3-fluoro-4-aminobenzoic acid methyl ester; Methyl 2-bromo-3-fluoro-4-aminobenzoate; 1427423-64-0
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Amino-2-Bromo-3-Fluorobenzoate adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthetic processes. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to minimize exposure to atmospheric humidity. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.