Description

Methyl 4-Amino-3-Chloro-5-Fluorobenzoate is a high-purity, multi-functional aromatic ester building block of significant importance in advanced organic synthesis. Its molecular structure, featuring strategically placed amino, chloro, and fluoro substituents, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates for oncology, CNS disorders, and anti-infective therapies.
• Agrochemical Synthesis: Serves as a critical building block for creating advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Research: Used in the development of specialized fluorinated aromatic compounds for electronic display technologies and organic light-emitting diodes.
• Dye & Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and pigments, leveraging the amino and halogen groups for color tuning and stability.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) due to the reactive chloro group, enabling rapid diversification of molecular libraries.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialty fluorinated intermediates.

Basic Information

Product Name	Methyl 4-Amino-3-Chloro-5-Fluorobenzoate
CAS No.	1427420-66-3
Molecular Formula	C8H7ClFNO2
Molecular Weight	203.60 g/mol
Synonyms	4-Amino-3-chloro-5-fluorobenzoic acid methyl ester; Methyl 4-amino-3-chloro-5-fluorobenzoate; 3-Chloro-5-fluoro-4-aminobenzoic acid methyl ester; Benzoic acid, 4-amino-3-chloro-5-fluoro-, methyl ester; Methyl 3-chloro-5-fluoro-4-aminobenzoate
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Amino-3-Chloro-5-Fluorobenzoate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical parameters. Our quality system is designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical and advanced material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.