Description

3-Chloro-2-Fluoro-4-Methylbenzoic Acid is a high-value, multi-functional aromatic carboxylic acid building block, distinguished by its strategic halogen substitution pattern. This compound is critical for researchers and process chemists requiring precise molecular architecture in advanced synthesis. It is primarily utilized in the pharmaceutical and agrochemical industries for the development of novel active ingredients, where its unique structure enables fine-tuning of biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and pesticides, leveraging the halogen atoms for bioactivity.
• Liquid Crystal & OLED Materials: Used in the synthesis of specialized organic molecules for electronic displays and lighting applications due to its stable aromatic core and substitution sites.
• Polymer Modification: Acts as a monomer or functionalizing agent to introduce carboxylic acid and halogen functionalities into polymer chains, altering material properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a scaffold for constructing more complex polyfunctional aromatic compounds in R&D.
• Chemical Research & Development: Essential for academic and industrial research exploring new chemical entities, reaction methodologies, and structure-activity relationships.

Basic Information

Product Name	3-Chloro-2-Fluoro-4-Methylbenzoic Acid
CAS No.	1427416-06-5
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	2-Fluoro-3-chloro-4-methylbenzoic acid; 4-Methyl-3-chloro-2-fluorobenzoic acid; Benzoic acid, 3-chloro-2-fluoro-4-methyl-; 3-Chloro-2-fluoro-p-toluic acid; 2-Fluoro-3-chloro-p-toluic acid; 3-Chloro-2-fluoro-4-methyl-benzoic acid (IUPAC); 3-Cl-2-F-4-Me-BA
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluoro-4-Methylbenzoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.