Description

3-(Benzyloxy)-2,6-Difluorobenzoic Acid is a high-purity, multi-functional benzoic acid derivative distinguished by its benzyl-protected phenolic oxygen and strategic fluorine substitution. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block for the synthesis of complex organic molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce specific steric and electronic properties into their target compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, where the difluoro-benzoic acid core contributes to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and polymers requiring specific fluorine-containing aromatic units.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Industrial R&D: Fundamental research reagent in organic chemistry for studying fluorination effects and developing new synthetic methodologies.

Basic Information

Product Name	3-(Benzyloxy)-2,6-Difluorobenzoic Acid
CAS No.	1421604-28-5
Molecular Formula	C14H10F2O3
Molecular Weight	264.23 g/mol
Synonyms	2,6-Difluoro-3-(phenylmethoxy)benzoic Acid; Benzoic acid, 2,6-difluoro-3-(phenylmethoxy)-; 3-(Benzyloxy)-2,6-difluorobenzoic acid; 2,6-Difluoro-3-benzyloxybenzoic Acid; 3-Benzyloxy-2,6-difluorobenzoic Acid; BDFBA; 1421604-28-5
EINECS	Contact for details

Quality Control

Every batch of 3-(Benzyloxy)-2,6-Difluorobenzoic Acid is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes comprehensive analysis via HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards for relevant applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.