Description

25-Deacetyl-23-Acetyl Rifampicin is a key semi-synthetic derivative and an important intermediate in the synthesis of advanced rifamycin antibiotics. This compound matters for its role in developing next-generation antimicrobial agents with potentially improved pharmacokinetic profiles or reduced resistance. Pharmaceutical R&D laboratories and fine chemical manufacturers specializing in active pharmaceutical ingredients (APIs) require this high-purity intermediate for their synthesis and development programs.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of novel rifampicin analogs and other rifamycin-class antibiotics.
• Antimicrobial Research: Serves as a critical building block in medicinal chemistry for developing new anti-tuberculosis and antibacterial agents.
• Process Chemistry: Used in scale-up and optimization of manufacturing routes for complex antibiotic APIs.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.
• Biochemical Research: Utilized in studies investigating bacterial RNA polymerase inhibition and mechanisms of antibiotic action.

Basic Information

Item	Details
Product Name	25-Deacetyl-23-Acetyl Rifampicin
CAS No.	1416773-23-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Rifampicin 25-Deacetyl-23-Acetate; 23-Acetyl-25-deacetylrifampicin; 25-Deacetyl-23-O-acetylrifampicin; Rifampicin Derivative 1416773-23-3; 23-Acetyl-25-deacetylrifampin; Rifamycin SV Derivative; 25-Desacetyl-23-acetylrifampicin
EINECS	Contact for details

Quality Control

Our 25-Deacetyl-23-Acetyl Rifampicin is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Orange to Red Powder
Identification (HPLC/IR)	Conforms to Standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Guidelines
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.