Description

4-Benzyloxy-3,5-Difluorobenzoic Acid is a high-purity fluorinated benzoic acid derivative characterized by its benzyl-protected phenolic oxygen and difluoro substitution pattern. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis, enabling the introduction of a functionalized benzoic acid moiety. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the creation of novel active molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, where the difluoro and benzyloxy groups modulate biological activity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores essential in advanced electronic displays and organic light-emitting diodes.
• Polymer Modification: Employed to introduce fluorinated aromatic units into polymer backbones, enhancing thermal stability, chemical resistance, and optical properties of specialty polymers.
• Cross-Coupling Reactions: The carboxylic acid group allows for easy conversion to esters, amides, or acid halides, making it a versatile substrate for Suzuki, Sonogashira, and other palladium-catalyzed couplings.
• Chemical Research & Development: A valuable reagent for academic and industrial research exploring new fluorinated compounds and their physicochemical properties.

Basic Information

Product Name	4-Benzyloxy-3,5-Difluorobenzoic Acid
CAS No.	1408143-67-8
Molecular Formula	C14H10F2O3
Molecular Weight	264.22 g/mol
Synonyms	3,5-Difluoro-4-(phenylmethoxy)benzoic Acid; Benzoic acid, 3,5-difluoro-4-(phenylmethoxy)-; 4-(Benzyloxy)-3,5-difluorobenzoic Acid; 3,5-Difluoro-4-(benzyloxy)benzoic Acid; 4-(Phenylmethoxy)-3,5-difluorobenzoic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Benzyloxy-3,5-Difluorobenzoic Acid is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality control protocol includes identity confirmation by spectroscopic methods and purity assessment by HPLC. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support custom synthesis and can tailor specifications to meet specific project requirements, including compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.