Description

(Dl)-4-(trans-2-(Trifluoromethyl)-Cyclopropyl)Benzoic Acid CAS NO 1404192-14-8 is a high-value, fluorinated benzoic acid derivative featuring a cyclopropyl substituent. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is essential for research and development teams in the pharmaceutical and agrochemical sectors, where its unique trifluoromethyl-cyclopropyl motif is leveraged to modulate the biological activity, metabolic stability, and physicochemical properties of target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Serves as a building block for creating new-generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Liquid Crystal & OLED Material Research: Used in the synthesis of fluorinated organic compounds for electronic and optoelectronic applications.
• Organic Synthesis & Catalysis: Acts as a precursor for ligands or as a sterically defined, fluorinated aromatic acid in coupling reactions and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Employed as a probe or tag molecule due to the distinctive properties imparted by the fluorine atoms and rigid cyclopropyl ring.
• Material Science: A monomer or modifier for synthesizing specialty polymers with specific thermal, chemical, or surface properties.

Basic Information

Product Name	(Dl)-4-(trans-2-(Trifluoromethyl)-Cyclopropyl)Benzoic Acid
CAS No.	1404192-14-8
Molecular Formula	C11H9F3O2
Molecular Weight	230.18 g/mol
Synonyms	4-[(1R,2S)-2-(Trifluoromethyl)cyclopropyl]benzoic Acid (enantiomer-specific); 4-(trans-2-(Trifluoromethyl)cyclopropyl)benzoic Acid; DL-4-(2-(Trifluoromethyl)cyclopropyl)benzoic Acid; Benzoic acid, 4-[trans-2-(trifluoromethyl)cyclopropyl]-; trans-4-(2-(Trifluoromethyl)cyclopropyl)benzoic Acid; (±)-4-(trans-2-(Trifluoromethyl)cyclopropyl)benzoic Acid; TFM-CPBA (abbreviation)
EINECS	Contact for details

Quality Control

Our production of (Dl)-4-(trans-2-(Trifluoromethyl)-Cyclopropyl)Benzoic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our facilities operate under a cGMP-aligned quality system to guarantee traceability and reliability for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.