Description

Methyl 2-Amino-4-Bromo-5-Fluorobenzoate CAS NO 1395493-30-7 is a high-purity fluorinated benzoate derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a multifunctional aromatic core with halogen and amine handles for selective derivatization, enabling the construction of complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Used in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its halogenated aromatic structure.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing molecular probes, enzyme inhibitors, and bioconjugation reagents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development of scalable synthetic routes.
• Academic & R&D Laboratories: Utilized in medicinal chemistry programs and methodology development for cross-coupling and amidation reactions.

Basic Information

Product Name	Methyl 2-Amino-4-Bromo-5-Fluorobenzoate
CAS No.	1395493-30-7
Molecular Formula	C8H7BrFNO2
Molecular Weight	248.05 g/mol
Synonyms	2-Amino-4-bromo-5-fluorobenzoic acid methyl ester; Methyl 2-amino-4-bromo-5-fluorobenzoate; Benzoic acid, 2-amino-4-bromo-5-fluoro-, methyl ester; 4-Bromo-5-fluoro-2-aminobenzoic acid methyl ester; 5-Fluoro-2-amino-4-bromobenzoic acid methyl ester; Methyl 5-fluoro-2-amino-4-bromobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 2-Amino-4-Bromo-5-Fluorobenzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. For custom synthesis projects, we adhere to cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container must be kept tightly sealed due to the light-sensitive nature of the compound.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.