Description

Methyl 3-Amino-2,6-Difluorobenzoate Hydrochloride is a high-purity, functionalized benzoate derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of amino and fluorine substituents, which are essential for modulating the biological activity and physicochemical properties of target molecules. This intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro and amino groups contribute to enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functional polymers and advanced organic electronic materials due to its aromatic core and modifiable functional groups.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity, complex fluorinated intermediates.

Basic Information

Product Name	Methyl 3-Amino-2,6-Difluorobenzoate Hydrochloride
CAS No.	1392273-41-4
Molecular Formula	C8H8F2NO2·HCl
Molecular Weight	223.61 (Free base) / 260.07 (HCl salt)
Synonyms	3-Amino-2,6-difluorobenzoic acid methyl ester hydrochloride; Methyl 3-amino-2,6-difluorobenzoate HCl; Benzoic acid, 3-amino-2,6-difluoro-, methyl ester, hydrochloride; 2,6-Difluoro-3-aminobenzoic acid methyl ester hydrochloride; Methyl 2,6-difluoro-3-aminobenzoate hydrochloride
EINECS	Contact for details

Quality Control

Our production of Methyl 3-Amino-2,6-Difluorobenzoate Hydrochloride adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against established internal specifications, which are aligned with industry best practices for advanced pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.