Description

4-Methoxy-2,3,5,6-Tetrfluorobenzotrichloride is a highly functionalized aromatic intermediate, specifically a benzotrichloride derivative with methoxy and tetrafluoro substitutions. This unique structure makes it a valuable building block for synthesizing complex molecules where precise electronic and steric properties are required. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and advanced agrochemical industries for creating novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used to construct advanced herbicide and pesticide molecules, leveraging the stability and lipophilicity imparted by the fluorine atoms.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in high-performance displays.
• Polymer Modification: Intermediate for introducing fluorinated aromatic units into specialty polymers to enhance chemical resistance, thermal stability, and dielectric properties.
• Organic Electronics: Precursor for materials used in organic light-emitting diodes (OLEDs) and semiconductors, where the methoxy and fluoro groups tune electron transport.
• Complex Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Methoxy-2,3,5,6-Tetrfluorobenzotrichloride
CAS No.	1391033-24-1
Molecular Formula	C8H2Cl3F4O
Molecular Weight	295.45 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-methoxybenzotrichloride; 1-(Trichloromethyl)-2,3,5,6-tetrafluoro-4-methoxybenzene; Benzene, 1-(trichloromethyl)-2,3,5,6-tetrafluoro-4-methoxy-; 4-Methoxy-2,3,5,6-tetrafluorobenzene-1-(trichloromethyl); α,α,α-Trichloro-2,3,5,6-tetrafluoro-4-methoxytoluene
EINECS	Contact for details

Quality Control

Our 4-Methoxy-2,3,5,6-Tetrfluorobenzotrichloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis of the trichloromethyl group. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.