Description

2,3,5-Trifluorocinnamic Acid is a high-value fluorinated aromatic building block characterized by its cinnamic acid backbone with a specific trifluoro substitution pattern. This compound is essential for introducing fluorine atoms into target molecules, a key strategy in modern medicinal and agrochemical research to fine-tune properties like metabolic stability, lipophilicity, and bioavailability. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of fluorinated drug candidates, particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where fluorine substitution enhances activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Peptide Mimetics & Bio-conjugation: The carboxylic acid group allows for coupling reactions to create fluorinated peptide analogs or for use in bioconjugation linkers.
• Material Science Research: Employed in the synthesis of novel fluorinated polymers and specialty chemicals with unique surface properties.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Product Name	2,3,5-Trifluorocinnamic Acid
CAS No.	1384157-92-9
Molecular Formula	C9H5F3O2
Molecular Weight	202.13 g/mol
Synonyms	(2E)-3-(2,3,5-Trifluorophenyl)prop-2-enoic acid; trans-2,3,5-Trifluorocinnamic Acid; 2,3,5-Trifluorocinnameic Acid; β-(2,3,5-Trifluorophenyl)acrylic Acid; 3-(2,3,5-Trifluorophenyl)-2-propenoic Acid
EINECS	Contact for details

Quality Control

Our 2,3,5-Trifluorocinnamic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.