Description

Methyl 2-Fluoro-3-[4-Fluoro-3-(Methoxycarbonyl)Phenyl]Benzoate is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. This compound matters as a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its specific fluorine substitution pattern enables precise tuning of biological activity and physicochemical properties. It is primarily needed by research chemists and process development scientists working on novel active ingredients, including kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of fluorinated drug candidates, especially kinase inhibitors and anti-cancer agents.
• Agrochemical Synthesis: Used in the creation of advanced, high-performance herbicides and pesticides where fluorine atoms enhance stability and efficacy.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and liquid crystals with unique electronic properties.
• Organic Light-Emitting Diode (OLED) Materials: A potential building block for electron-transport or emissive layer materials in display technologies.
• Chemical Biology Probes: Utilized in the synthesis of fluorinated probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthesis projects requiring complex fluorinated intermediates.

Basic Information

Product Name	Methyl 2-Fluoro-3-[4-Fluoro-3-(Methoxycarbonyl)Phenyl]Benzoate
CAS No.	1381944-72-4
Molecular Formula	C16H12F2O4
Molecular Weight	306.26 g/mol
Synonyms	2-Fluoro-3-(4-fluoro-3-methoxycarbonylphenyl)benzoic acid methyl ester; Methyl 2-fluoro-3-(4-fluoro-3-(methoxycarbonyl)phenyl)benzoate; Benzoic acid, 2-fluoro-3-[4-fluoro-3-(methoxycarbonyl)phenyl]-, methyl ester; 1381944-72-4; 3-(4-Fluoro-3-methoxycarbonylphenyl)-2-fluorobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Fluoro-3-[4-Fluoro-3-(Methoxycarbonyl)Phenyl]Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with consistent quality that meets the stringent requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.