Description

4-(Cyclobutylmethoxy)-3,5-Difluorobenzoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorinated benzoic acid core with a cyclobutylmethoxy substituent. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, agrochemicals, and specialty organic materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug molecules, especially in oncology, neurology, and anti-inflammatory therapies.
• Agrochemical Synthesis: Serves as a precursor for developing novel herbicides, fungicides, and pesticides with enhanced efficacy.
• Organic Light-Emitting Diode (OLED) Materials: Used in the synthesis of specialized electron-transport or host materials for electronic displays.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalytic processes.
• Academic and Industrial R&D: A valuable reagent for methodological studies in organic synthesis and fluorochemistry.
• Fine Chemical Production: Incorporated into the manufacture of complex, high-value specialty chemicals.

Basic Information

Product Name	4-(Cyclobutylmethoxy)-3,5-Difluorobenzoic Acid
CAS No.	1380300-36-6
Molecular Formula	C₁₂H₁₂F₂O₃
Molecular Weight	242.22 g/mol
Synonyms	3,5-Difluoro-4-(cyclobutylmethoxy)benzoic Acid; Benzoic acid, 3,5-difluoro-4-(cyclobutylmethoxy)-; 4-(Cyclobutylmethoxy)-3,5-difluorobenzoic acid; 1380300-36-6; 3,5-Difluoro-4-[(cyclobutylmethyl)oxy]benzoic acid
EINECS	Contact for details

Quality Control

Our 4-(Cyclobutylmethoxy)-3,5-Difluorobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.