Description

Methyl 4-Bromo-5-Chloro-2-Fluorobenzoate is a high-purity fluorinated aromatic ester building block, essential for advanced organic synthesis. Its value lies in its multifunctional halogenated structure, which provides versatile reactivity for constructing complex molecules with precision. This intermediate is critically needed by pharmaceutical and agrochemical R&D laboratories for the development of new active ingredients, particularly in medicinal chemistry for creating novel drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules containing fluorinated benzoate motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where halogenated aromatic rings are required.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and other functional materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the bromo substituent.
• Chemical Derivatization: The ester group allows for further functionalization, including hydrolysis to the corresponding acid or transesterification.
• Organic Synthesis Scaffold: Used in academic and industrial research for constructing complex polycyclic or heterocyclic compounds.

Basic Information

Product Name	Methyl 4-Bromo-5-Chloro-2-Fluorobenzoate
CAS No.	1379366-11-6
Molecular Formula	C8H5BrClFO2
Molecular Weight	267.48 g/mol
Synonyms	4-Bromo-5-chloro-2-fluorobenzoic acid methyl ester; Methyl 4-bromo-5-chloro-2-fluorobenzoate; Benzoic acid, 4-bromo-5-chloro-2-fluoro-, methyl ester; 2-Fluoro-4-bromo-5-chlorobenzoic acid methyl ester; Methyl 2-fluoro-4-bromo-5-chlorobenzoate; 1379366-11-6; 4-Bromo-5-chloro-2-fluorobenzoic acid, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 4-Bromo-5-Chloro-2-Fluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring material that meets stringent internal specifications or compendial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.