Description

2-Fluoro-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoic Acid is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, specifically the Suzuki-Miyaura reaction, which is fundamental for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, catalyst development, and the synthesis of functional organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage the Suzuki coupling for structure-activity relationship (SAR) studies.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and diagnostics.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CROs (Contract Research Organizations) serving the global chemical industry.

Basic Information

Product Name	2-Fluoro-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoic Acid
CAS No.	1373168-89-8
Molecular Formula	C₁₃H₁₆BFO₄
Molecular Weight	266.08 g/mol
Synonyms	2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid; 3-Borono-2-fluorobenzoic acid, pinacol ester; 2-Fluoro-3-(pinacolatoboryl)benzoic acid; 2-Fluoro-3-boronobenzoic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluorobenzoic acid; 2-Fluoro-3-(pinacol boronate)benzoic acid; 2-Fluoro-3-boronobenzoic acid, 1,3-propanediol cyclic ester (pinacol); 2-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and traceability, meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.