Description

2-{1-[3-(Trifluoromethyl)Phenyl]Cyclobutyl}Acetic Acid is a high-value, synthetically versatile trifluoromethylated cyclobutane derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a sophisticated building block in modern organic synthesis. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate the unique physicochemical properties of the trifluoromethyl group and the strained cyclobutane ring into novel molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Building block for developing new-generation herbicides and fungicides, where the trifluoromethyl group enhances bioavailability and metabolic stability.
• Ligand & Catalyst Development: Used in the creation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Intermediate for synthesizing specialty polymers and liquid crystals with tailored thermal and optical properties.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fluorine Chemistry: Serves as a model compound for studying the influence of the -CF3 group on reaction pathways and molecular conformation.

Basic Information

Product Name	2-{1-[3-(Trifluoromethyl)Phenyl]Cyclobutyl}Acetic Acid
CAS No.	1358805-28-3
Molecular Formula	C13H13F3O2
Molecular Weight	258.24 g/mol
Synonyms	2-[1-[3-(Trifluoromethyl)phenyl]cyclobutyl]acetic acid; 1-[3-(Trifluoromethyl)phenyl]cyclobutane-1-acetic acid; 2-(1-(3-(Trifluoromethyl)phenyl)cyclobutyl)acetic acid; α-(1-(m-Trifluoromethylphenyl)cyclobutyl)acetic acid; 3-Trifluoromethyl-α-cyclobutylbenzeneacetic acid
EINECS	Contact for details

Quality Control

Our production of 2-{1-[3-(Trifluoromethyl)Phenyl]Cyclobutyl}Acetic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization using HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.