Description

Dbco-Acid CAS NO 1353016-70-2 is a high-purity, functionalized chemical building block featuring a dibenzocyclooctyne (DBCO) group and a carboxylic acid moiety. This bifunctional structure is critical for enabling strain-promoted azide-alkyne cycloaddition (SPAAC), a cornerstone bioorthogonal "click chemistry" reaction. It is an essential reagent for researchers and manufacturers in life sciences, material science, and pharmaceutical development who require efficient, catalyst-free conjugation strategies.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific labeling of proteins, antibodies, and peptides for diagnostics and targeted therapeutics.
• Probe and Sensor Synthesis: Construction of fluorescent, biotinylated, or other functional probes for cellular imaging and detection assays.
• Polymer and Material Functionalization: Surface modification of nanoparticles, hydrogels, and polymers to introduce bioactive ligands or alter material properties.
• Chemical Biology and Drug Discovery: Tool compound synthesis for target identification, activity-based protein profiling, and library construction.
• Diagnostic Kit Manufacturing: Conjugation of detection molecules (enzymes, dyes) to solid supports or other biomolecules in lateral flow assays and ELISA.
• Glycan and Oligonucleotide Labeling: Modification of carbohydrates and nucleic acids for tracking and interaction studies.

Basic Information

Product Name	Dbco-Acid
CAS No.	1353016-70-2
Molecular Formula	C18H12N2O3
Molecular Weight	304.30 g/mol
Synonyms	DBCO-COOH; Dibenzocyclooctyne-acid; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2,5-dioxopyrrolidin-1-yl) carbonate; Azadibenzocyclooctyne-COOH; ADIBO-acid; DBCO-C1-acid; 3-(3-((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethoxy)-3-oxopropyl)-1-methyl-1H-pyrrole-2,5-dione (common misassignment); SPAAC reagent acid
EINECS	Contact for details

Quality Control

Our Dbco-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.