Description

Ortho-Nitroveratryloxycarbonyl-Q-Rhodamine-5-Peg3-Azide is a multifunctional, high-purity chemical building block designed for advanced bioconjugation and labeling applications. This compound matters for its unique combination of a photolabile protecting group (o-Nitroveratryloxycarbonyl, NVOC), a bright fluorescent rhodamine dye, a hydrophilic PEG3 spacer, and a bioorthogonal azide handle, enabling precise, light-controlled, and site-specific modifications. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require sophisticated tools for creating targeted imaging probes, drug conjugates, and functional biomaterials.

Application

• Bioconjugation & Probe Development: Site-specific labeling of proteins, antibodies, and oligonucleotides via copper-free click chemistry with azide-reactive partners.
• Controlled Release Systems: Creation of "caged" compounds where the NVOC group allows for the light-triggered, spatiotemporally controlled release of active molecules or fluorophores.
• Live-Cell Imaging: Synthesis of cell-permeable fluorescent tags for real-time visualization of cellular processes and target engagement.
• ADC (Antibody-Drug Conjugate) Research: Construction of novel linker-payload architectures for targeted cancer therapeutics.
• Surface Functionalization: Modification of nanoparticles, polymers, and biosensor surfaces with fluorescent and reactive groups.
• Chemical Biology Tools: Development of activity-based probes (ABPs) and photoaffinity labels for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	Ortho-Nitroveratryloxycarbonyl-Q-Rhodamine-5-Peg3-Azide
CAS No.	1352809-21-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	NVOC-Q-Rhodamine-5-PEG3-Azide; o-Nitroveratryloxycarbonyl-Q-Rhodamine-5-PEG3-N3; Q-Rhodamine 5-PEG3-Azide NVOC protected; Photocleavable Rhodamine-PEG3-Azide; Light-activatable fluorescent azide; 5(6)-Q-Rhodamine-PEG3-Azide NVOC ester
EINECS	Contact for details

Quality Control

Every batch of Ortho-Nitroveratryloxycarbonyl-Q-Rhodamine-5-Peg3-Azide is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity (HPLC), identity (NMR, MS), and functional integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant (e.g., in a sealed bag with silica gel) due to its hygroscopic and light-sensitive nature. For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Red to purple solid or powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 1.0%
Functional Group Integrity	Confirmed by NMR / Functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.