Description

Methyl 4-(2-Cyanophenyl)-2-Fluorobenzoate is a high-purity fluorinated aromatic ester building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. Pharmaceutical R&D teams and fine chemical manufacturers need it for its precise molecular architecture, which enables the introduction of both cyano and fluoro substituents in a single, versatile synthon.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a key starting material for synthesizing fluorinated aromatic cores used in electronic display technologies.
• Polymer Modification: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or optical properties.
• Cross-Coupling Reactions: Utilized in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and exploring new chemical spaces.

Basic Information

Product Name	Methyl 4-(2-Cyanophenyl)-2-Fluorobenzoate
CAS No.	1352317-81-7
Molecular Formula	C15H10FNO2
Molecular Weight	255.25 g/mol
Synonyms	Methyl 2-Fluoro-4'-(2-cyanophenyl)benzoate; 4-(2-Cyanophenyl)-2-Fluorobenzoic Acid Methyl Ester; 2-Fluoro-4'-(2-cyanophenyl)benzoic Acid Methyl Ester; Benzoic acid, 4-(2-cyanophenyl)-2-fluoro-, methyl ester; Methyl 4-(2-cyanophenyl)-2-fluorobenzoate; Methyl 2-fluoro-[1,1'-biphenyl]-4-carboxylate-2'-carbonitrile
EINECS	Contact for details

Quality Control

Our production of Methyl 4-(2-Cyanophenyl)-2-Fluorobenzoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and MS, to confirm identity and quantify impurities. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP and ISO standards for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.