Description

5-(4-Aminophenyl)-2-Fluorobenzoic Acid is a high-purity, multi-functional aromatic building block featuring both an amine and a carboxylic acid group. This compound is critical for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in kinase inhibitor and anti-cancer agent research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, leveraging its bifunctional reactivity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic and display materials.
• Polymer & Resin Modifier: Incorporated to introduce amine or carboxylic acid functionality into polymer chains for enhanced properties.
• Peptide Mimetics & Bioconjugation: The orthogonal reactive groups make it valuable for creating peptide analogs and linker molecules in bioconjugation chemistry.
• Chemical Research & Development: A versatile building block for exploratory synthesis in academic and industrial R&D laboratories.

Basic Information

Product Name	5-(4-Aminophenyl)-2-Fluorobenzoic Acid
CAS No.	1345471-46-6
Molecular Formula	C13H10FNO2
Molecular Weight	231.22 g/mol
Synonyms	2-Fluoro-5-(4-aminophenyl)benzoic Acid; 4'-Amino-2-fluorobiphenyl-4-carboxylic Acid; 5-(4-Aminophenyl)-2-fluorobenzoic acid; [1,1'-Biphenyl]-4-carboxylic acid, 4'-amino-2-fluoro-; 2-Fluoro-5-(4-aminophenyl)benzoic acid; 4-Amino-4'-(2-fluorobenzoic acid)biphenyl
EINECS	Contact for details

Quality Control

Our 5-(4-Aminophenyl)-2-Fluorobenzoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF for moisture content, to ensure it meets the high standards required for research and production. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.