Description

2-(2,5-Difluorophenyl)-2,2-Difluoroacetic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is critical for modulating biological activity, metabolic stability, and lipophilicity. It is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate a difluorophenylacetic acid moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in therapeutic areas targeting the central nervous system, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where fluorination enhances efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Fluorinated Polymer Modification: Acts as a monomer or modifier in the production of specialty polymers with enhanced chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new fluorination methodologies and creating compound libraries for screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific fluorinated target molecules.

Basic Information

Product Name	2-(2,5-Difluorophenyl)-2,2-Difluoroacetic Acid
CAS No.	1339922-71-2
Molecular Formula	C8H4F4O2
Molecular Weight	208.11 g/mol
Synonyms	2,2-Difluoro-2-(2,5-difluorophenyl)acetic Acid; α,α-Difluoro-2,5-difluorophenylacetic Acid; 2-(2,5-Difluorophenyl)-2,2-difluoroethanoic Acid; (2,5-Difluorophenyl)difluoroacetic Acid; DFDFPA; 2,5-Difluorophenyl(difluoro)acetic Acid
EINECS	Contact for details

Quality Control

Our 2-(2,5-Difluorophenyl)-2,2-Difluoroacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical and agrochemical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.