Description

4-Cyclobutoxy-3,5-Difluorobenzoic Acid is a high-purity fluorinated benzoic acid derivative serving as a critical building block in advanced organic synthesis. Its value lies in the unique cyclobutoxy and difluoro substitution pattern, which imparts specific steric and electronic properties to target molecules. This compound is primarily needed by pharmaceutical and agrochemical R&D sectors for the development of novel active ingredients, particularly where fine-tuning of lipophilicity and metabolic stability is required.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of new drug candidates, especially in kinase inhibitor and anti-inflammatory agent discovery.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: A potential precursor for fluorine-containing liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Serves as a building block for electron-transport materials or semiconductors in OLEDs and OFETs.
• Chemical Research: Employed in academic and industrial laboratories for method development and exploring new fluorination chemistry.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	4-Cyclobutoxy-3,5-Difluorobenzoic Acid
CAS No.	1339696-85-3
Molecular Formula	C11H10F2O3
Molecular Weight	228.19 g/mol
Synonyms	3,5-Difluoro-4-cyclobutoxybenzoic Acid; Benzoic acid, 3,5-difluoro-4-cyclobutoxy-; 4-(Cyclobutyloxy)-3,5-difluorobenzoic Acid; 3,5-Difluoro-4-(cyclobutyloxy)benzoic Acid; 1339696-85-3; 4-Cyclobutoxy-3,5-difluorobenzoate
EINECS	Contact for details

Quality Control

Our production of 4-Cyclobutoxy-3,5-Difluorobenzoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP standards for pharmaceutical applications and can accommodate custom purity requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.