Description

tert-Butyl 2,3-Difluorobenzoate is a high-purity fluorinated benzoate ester derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic placement of fluorine atoms and the tert-butyl ester protecting group, which enables precise molecular construction for complex target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those requiring a difluorinated aromatic core for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated organic electronic materials for displays and lighting applications.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, after hydrolysis to the corresponding carboxylic acid or transesterification.
• Chemical Research & Development: A valuable tool in academic and industrial R&D for exploring new fluorination methodologies and constructing complex molecular architectures.

Basic Information

Product Name	tert-Butyl 2,3-Difluorobenzoate
CAS No.	1339524-27-4
Molecular Formula	C11H12F2O2
Molecular Weight	214.21 g/mol
Synonyms	2,3-Difluorobenzoic Acid tert-Butyl Ester; Benzoic acid, 2,3-difluoro-, 1,1-dimethylethyl ester; tert-Butyl 2,3-difluorobenzoate; 1,1-Dimethylethyl 2,3-difluorobenzoate; 2,3-Difluorobenzoic Acid 1,1-Dimethylethyl Ester; TBDFB
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,3-Difluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.