Description

1-(3-Fluoro-4-Methoxyphenyl)Cyclobutanecarboxylic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique cyclobutane and substituted phenyl ring structure imparts specific steric and electronic properties. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create new molecules with enhanced biological activity or material properties.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require fluorinated aromatic components.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials due to its rigid, fluorinated structure.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.
• Academic and Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including C-H activation and cross-coupling reactions.

Basic Information

Product Name	1-(3-Fluoro-4-Methoxyphenyl)Cyclobutanecarboxylic Acid
CAS No.	1314709-48-2
Molecular Formula	C12H13FO3
Molecular Weight	224.23 g/mol
Synonyms	1-(3-Fluoro-4-methoxyphenyl)cyclobutanecarboxylic acid; 3-Fluoro-4-methoxy-α-cyclobutanephenylacetic acid; Cyclobutanecarboxylic acid, 1-(3-fluoro-4-methoxyphenyl)-; 1-(3-Fluoro-4-methoxyphenyl)cyclobutane-1-carboxylic acid; 1314709-48-2; 3-Fluoro-4-methoxybenzenecyclobutanecarboxylic acid; 4-Methoxy-3-fluorophenyl cyclobutanecarboxylate (tautomer); FMO-CBA
EINECS	Contact for details

Quality Control

Our production of 1-(3-Fluoro-4-Methoxyphenyl)Cyclobutanecarboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. All materials are fully characterized and undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development under cGMP guidelines and can tailor quality specifications to meet the specific requirements of pharmaceutical or agrochemical regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.