Description

tert-Butyl 4-Amino-2-(Trifluoromethyl)Benzoate CAS NO 1311200-05-1 is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethyl-substituted benzoate structure. This compound is of significant commercial value for its role in streamlining the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, leveraging its aromatic and functional group diversity.
• Organic Synthesis & Catalysis: Employed in academic and industrial R&D for constructing complex organic frameworks and as a ligand in catalytic systems.
• Fluorine Chemistry Studies: A valuable compound for investigating the effects of fluorine substitution on molecular properties and reactivity.

Basic Information

Product Name	tert-Butyl 4-Amino-2-(Trifluoromethyl)Benzoate
CAS No.	1311200-05-1
Molecular Formula	C12H14F3NO2
Molecular Weight	261.24 g/mol
Synonyms	4-Amino-2-(trifluoromethyl)benzoic acid tert-butyl ester; tert-Butyl 4-amino-α,α,α-trifluoro-o-toluate; 2-(Trifluoromethyl)-4-aminobenzoic acid tert-butyl ester; Benzoic acid, 4-amino-2-(trifluoromethyl)-, 1,1-dimethylethyl ester; 4-Amino-α,α,α-trifluoro-2-methylbenzoic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Amino-2-(Trifluoromethyl)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.