Description

Ethyl 3-Bromo-2,6-Difluorobenzoate is a high-value, multi-functional fluorinated aromatic building block essential for advanced organic synthesis. Its core value lies in the strategic placement of bromine and fluorine substituents, which enable precise cross-coupling reactions and the introduction of lipophilicity and metabolic stability into target molecules. This compound is critically needed by R&D and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients, particularly in medicinal chemistry for creating novel heterocycles and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing difluorobenzene motifs for enhanced bioavailability and target binding.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine atoms improve compound stability and membrane permeability.
• Material Science Research: Serves as a monomer or building block for developing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and Negishi couplings to construct complex biaryl structures.
• Medicinal Chemistry: Employed in fragment-based drug discovery and for introducing fluorinated aromatic rings into candidate molecules to modulate pKa, lipophilicity (LogP), and metabolic resistance.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke intermediates for client projects.

Basic Information

Product Name	Ethyl 3-Bromo-2,6-Difluorobenzoate
CAS No.	1309933-04-7
Molecular Formula	C9H7BrF2O2
Molecular Weight	265.05 g/mol
Synonyms	3-Bromo-2,6-difluorobenzoic Acid Ethyl Ester; Ethyl 3-Bromo-2,6-difluorobenzoate; Benzoic acid, 3-bromo-2,6-difluoro-, ethyl ester; 2,6-Difluoro-3-bromobenzoic Acid Ethyl Ester; 3-Bromo-2,6-difluorobenzoic Acid Ethyl Ester; Ethyl 3-bromo-2,6-difluorobenzoate
EINECS	Contact for details

Quality Control

Every batch of Ethyl 3-Bromo-2,6-Difluorobenzoate is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards, and our in-house analytical lab utilizes advanced techniques like HPLC, GC, and NMR for verification. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥98.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residue on Ignition	<0.1%
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.