Description

Maleimido-Mono-Amide-Nota is a specialized heterobifunctional chelating agent designed for the site-specific conjugation of radionuclides to biomolecules. This compound is critical for creating stable, well-defined radiopharmaceuticals and diagnostic probes with precise targeting capabilities. It is essential for researchers and manufacturers in the fields of nuclear medicine, molecular imaging, and targeted radiotherapy who require high-purity, reliable linkers for developing next-generation theranostic agents.

Application

• Radiopharmaceutical Synthesis: Primary linker for attaching therapeutic (e.g., Lutetium-177, Actinium-225) or diagnostic (e.g., Gallium-68, Copper-64) radionuclides to antibodies, peptides, and other targeting vectors.
• PET/SPECT Imaging Probe Development: Enables the creation of stable chelates for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) contrast agents.
• Targeted Radionuclide Therapy (TRT): A key building block in the development of precision cancer therapeutics that deliver radiation directly to tumor cells.
• Bioconjugation & Protein Labeling: The maleimide group allows for stable thiol conjugation (e.g., to cysteine residues or reduced disulfide bonds) on proteins and peptides, while the NOTA moiety provides a high-affinity chelation site for trivalent metals.
• Preclinical Research & Drug Discovery: Used in academic and industrial R&D for studying biodistribution, pharmacokinetics, and the efficacy of novel radiologands.
• Kit Formulation for Clinical Use: A critical component in the development of cold kits for the convenient, on-site radiolabeling of targeting molecules in hospital radiopharmacies.

Basic Information

Item	Details
Product Name	Maleimido-Mono-Amide-Nota
CAS No.	1295584-83-6
Molecular Formula	C₂₀H₂₈N₆O₈
Molecular Weight	480.48 g/mol
Synonyms	NOTA-Maleimide; Maleimido-monoamide-NOTA; 2,2'-(7-(1-Carboxy-4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)amino)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic Acid; 1,4,7-Triazacyclononane-N,N',N''-triacetic Acid, Monoamide Maleimide Derivative; Maleimide-CHX-A''-NOTA; p-SCN-Bn-NOTA-Maleimide; NOTA-based Bifunctional Chelator
EINECS	Contact for details

Quality Control

Our Maleimido-Mono-Amide-Nota is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the stringent requirements for radiopharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.