Description

Dansyl Chloride-D6 is a deuterated derivative of the widely used fluorescent labeling reagent, dansyl chloride. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, providing enhanced accuracy and reliability in analytical workflows. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and environmental testing sectors who require precise quantification of amines, amino acids, and other nucleophilic analytes.

Application

• Internal Standard for LC-MS/MS: Serves as a critical stable-isotope-labeled internal standard for the accurate quantification of dansylated analytes in liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods.
• Proteomics & Metabolomics Research: Used in high-throughput screening and biomarker discovery studies for labeling and quantifying peptides, amino acids, and small molecule metabolites.
• Pharmaceutical Analysis: Enables precise measurement of drug substances, impurities, and degradation products in pharmacokinetic and bioanalytical studies.
• Food & Environmental Safety Testing: Applied in the detection and quantification of biogenic amines, pesticides, or environmental contaminants that can be derivatized for sensitive analysis.
• Quality Control in Chemical Synthesis: Acts as a reference standard to monitor reaction yields and purity in the synthesis of dansyl-conjugated compounds.

Basic Information

Product Name	Dansyl Chloride-D6
CAS No.	1276379-68-0
Molecular Formula	C12H6D6ClNO2S
Molecular Weight	286.80 g/mol
Synonyms	5-(Dimethylamino-d6)naphthalene-1-sulfonyl chloride; Dansyl-d6 chloride; DANSYL-D6 CHLORIDE; 5-(Dimethyl-d6-amino)naphthalene-1-sulfonyl chloride; 1-Dimethylaminonaphthalene-5-sulfonyl chloride-d6; DNS-Cl-d6; 1-(Dimethyl-d6-amino)naphthalene-5-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our Dansyl Chloride-D6 is manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is analyzed by NMR and mass spectrometry to confirm deuteration level and identity, and by HPLC to determine chemical purity. A comprehensive Certificate of Analysis (COA) detailing these specifications is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Deuteration Degree (Atom % D)	≥ 98%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.