Description

3,5-Difluoro-4-(Oxan-4-Yloxy)Benzoic Acid is a high-value fluorinated benzoic acid derivative featuring a tetrahydropyranyl (oxane) ether linkage. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block for the synthesis of complex organic molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors. The unique structural motif combining fluorine atoms and a protected ether group makes it essential for modulating the physicochemical properties of target compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, where the difluoro and ether groups contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores used in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Acts as a monomer or modifier for engineering plastics and high-performance polymers requiring specific dielectric or thermal properties.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for imaging and diagnostic applications due to its derivatizable carboxylic acid group.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.

Basic Information

Product Name	3,5-Difluoro-4-(Oxan-4-Yloxy)Benzoic Acid
CAS No.	1275432-84-2
Molecular Formula	C12H12F2O4
Molecular Weight	258.22 g/mol
Synonyms	4-(Oxan-4-yloxy)-3,5-difluorobenzoic Acid; 3,5-Difluoro-4-(tetrahydro-2H-pyran-4-yloxy)benzoic Acid; Benzoic acid, 3,5-difluoro-4-(tetrahydro-2H-pyran-4-yloxy)-; 3,5-Difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)benzoic Acid; 1275432-84-2; 4-(3,5-Difluoro-4-carboxyphenoxy)tetrahydropyran
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-(Oxan-4-Yloxy)Benzoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay, impurity profile, and residual solvents. Our quality commitment supports applications requiring cGMP compliance for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed to protect the contents from moisture absorption. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.