Description

Apx-115 Freebase CAS NO 1270084-92-8 is a high-purity, small molecule compound of significant interest in advanced pharmaceutical research and development. Its primary value lies in its role as a potent and selective inhibitor of the Keap1-Nrf2 protein-protein interaction, a key regulator of cellular oxidative stress response. This makes it a critical research tool and a promising candidate for therapeutic development. Industries requiring this compound include pharmaceutical R&D, biotechnology, and academic research institutions focused on developing treatments for conditions related to oxidative damage, such as neurodegenerative, inflammatory, and metabolic diseases.

Application

• Primary research into the Nrf2 signaling pathway and cellular defense mechanisms against oxidative stress.
• Preclinical development of novel therapeutics for neurodegenerative diseases (e.g., Parkinson's, Alzheimer's).
• Investigation of potential treatments for inflammatory and autoimmune disorders.
• Study of metabolic diseases and conditions involving mitochondrial dysfunction.
• Use as a reference standard in analytical method development and quality control for related pharmaceutical compounds.
• Exploratory research in oncology, investigating the role of Nrf2 in cancer cell survival and chemoresistance.

Basic Information

Product Name	Apx-115 Freebase
CAS No.	1270084-92-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	APX-115; Apx115; Keap1-Nrf2 PPI Inhibitor, APX-115; Nrf2 Activator APX-115; 2-[(4-{2-[(3,5-Dimethyl-4-isoxazolyl)methoxy]-6-methylpyridin-4-yl}-1H-pyrazol-1-yl)methyl]-1,3-thiazole-4-carboxylic Acid (Freebase)
EINECS	Contact for details

Quality Control

Our Apx-115 Freebase is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay, related substances, and residual solvents. We support our clients' regulatory needs with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (typically 15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect the hygroscopic material from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.