Description

4-Chloromethyl-3,5-Difluoro-Benzoic Acid Methyl Ester is a high-purity, multifunctional chemical intermediate designed for advanced synthesis. This compound is valued for its unique halogenated benzoate structure, which provides versatile reactivity for constructing complex molecular architectures. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for use in creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging its difluoro and chloromethyl groups for enhanced bioactivity and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a critical starting material for synthesizing fluorinated aromatic compounds used in electronic display technologies.
• Polymer Modification Agent: Employed to introduce functional benzoate groups into polymer chains, altering physical properties for specialty coatings and engineering plastics.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Organic Synthesis Research: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	4-Chloromethyl-3,5-Difluoro-Benzoic Acid Methyl Ester
CAS No.	1263283-69-7
Molecular Formula	C10H7ClF2O2
Molecular Weight	232.61 g/mol
Synonyms	Methyl 4-(Chloromethyl)-3,5-difluorobenzoate; 3,5-Difluoro-4-(chloromethyl)benzoic Acid Methyl Ester; Benzoic acid, 4-(chloromethyl)-3,5-difluoro-, methyl ester; Methyl 3,5-difluoro-4-(chloromethyl)benzoate
EINECS	Contact for details

Quality Control

Every batch of 4-Chloromethyl-3,5-Difluoro-Benzoic Acid Methyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and custom specifications can be developed to support your cGMP or research-grade projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.