Description

tert-Butyl 2-Bromo-5-Fluorobenzoate is a high-purity, synthetically valuable benzoate ester derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in providing a protected carboxylic acid group and strategically placed halogen substituents, enabling precise molecular construction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries, where it is used to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Liquid Crystal & OLED Material Research: Used in the creation of fluorinated aromatic cores for advanced electronic and photonic materials.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Protecting Group Strategy: The tert-butyl ester group offers a stable protecting group for carboxylic acids, which can be cleaved under mild acidic conditions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	tert-Butyl 2-Bromo-5-Fluorobenzoate
CAS No.	1263281-14-6
Molecular Formula	C11H12BrFO2
Molecular Weight	275.12 g/mol
Synonyms	2-Bromo-5-fluorobenzoic acid tert-butyl ester; Benzoic acid, 2-bromo-5-fluoro-, 1,1-dimethylethyl ester; tert-Butyl 2-bromo-5-fluorobenzoate; 1,1-Dimethylethyl 2-bromo-5-fluorobenzoate; 2-Bromo-5-fluorobenzoic acid 1,1-dimethylethyl ester; TB-2-Br-5-F-Bz; 1263281-14-6
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Bromo-5-Fluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.