Description

5-Amino-2-Fluoro-4-Methyl-Benzoic Acid is a high-purity fluorinated benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of amino and fluorine substituents on the aromatic ring, which are essential for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used as a precursor in the manufacture of advanced herbicides and pesticides, where the fluorine atom enhances bioavailability and stability.
• Liquid Crystal & OLED Material Precursor: Employed in the synthesis of fluorinated aromatic components for electronic display and lighting applications.
• Dye & Pigment Intermediate: Serves as a building block for creating specialized fluorinated dyes with unique color fastness and spectral properties.
• Chemical Research & Development: A versatile reagent for academic and industrial research in medicinal chemistry and material science.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid and amino groups allow for its incorporation into complex molecules and peptide backbones.

Basic Information

Product Name	5-Amino-2-Fluoro-4-Methyl-Benzoic Acid
CAS No.	1263277-38-8
Molecular Formula	C8H8FNO2
Molecular Weight	169.15 g/mol
Synonyms	2-Fluoro-4-methyl-5-aminobenzoic acid; 5-Amino-2-fluoro-p-toluic acid; Benzoic acid, 5-amino-2-fluoro-4-methyl-; 4-Methyl-5-amino-2-fluorobenzoic acid; 2-Fluoro-5-amino-4-methylbenzoic acid; 5-Amino-2-fluoro-4-methylbenzoic acid; AFMBA
EINECS	Contact for details

Quality Control

Our 5-Amino-2-Fluoro-4-Methyl-Benzoic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.