Description

3',5'-Difluoro-5-(Trifluoromethyl)-[1,1'-Biphenyl]-3-Carboxylic Acid is a high-value, multi-fluorinated biphenyl carboxylic acid derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring both difluoro and trifluoromethyl substituents, makes it indispensable for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers, liquid crystals, and organic electronic materials with tailored properties.
• Chemical Biology & Probe Development: Utilized as a scaffold for creating fluorescent probes, enzyme inhibitors, and other tools for biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A pivotal starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards for client-specific molecules.

Basic Information

Product Name	3',5'-Difluoro-5-(Trifluoromethyl)-[1,1'-Biphenyl]-3-Carboxylic Acid
CAS No.	1261950-34-8
Molecular Formula	C14H7F5O2
Molecular Weight	302.20 g/mol
Synonyms	5-(Trifluoromethyl)-3',5'-difluoro-[1,1'-biphenyl]-3-carboxylic acid; 3',5'-Difluoro-5-(trifluoromethyl)biphenyl-3-carboxylic acid; [1,1'-Biphenyl]-3-carboxylic acid, 3',5'-difluoro-5-(trifluoromethyl)-; 3-(3,5-Difluorophenyl)-5-(trifluoromethyl)benzoic acid
EINECS	Contact for details

Quality Control

Our production of 3',5'-Difluoro-5-(Trifluoromethyl)-[1,1'-Biphenyl]-3-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, and our facilities support production under quality systems suitable for advanced intermediate applications. Specifications can be tailored to meet specific research or cGMP requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.