Description

3'-Fluoro-2,4'-Dimethyl-[1,1'-Biphenyl]-4-Carboxylic Acid is a high-purity biphenyl carboxylic acid derivative, distinguished by its strategically placed fluorine and methyl substituents. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in modern organic synthesis. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides, where the biphenyl core provides structural stability and bioactivity.
• Liquid Crystal & OLED Materials: Acts as a precursor for the synthesis of fluorinated biphenyl-based compounds used in electronic display technologies and organic light-emitting diodes.
• Ligand & Catalyst Development: The carboxylic acid functionality allows for derivatization into chiral ligands or metal-organic frameworks (MOFs) for asymmetric catalysis.
• Polymer Modification: Employed to introduce aromatic and fluorinated units into polymer backbones to enhance thermal stability, chemical resistance, and optical properties.
• Academic & Contract Research: Serves as a valuable reagent for methodological studies in cross-coupling reactions and fluorination chemistry within academic and CRO laboratories.

Basic Information

Product Name	3'-Fluoro-2,4'-Dimethyl-[1,1'-Biphenyl]-4-Carboxylic Acid
CAS No.	1261939-39-2
Molecular Formula	C15H13FO2
Molecular Weight	244.26 g/mol
Synonyms	4-(3'-Fluoro-2,4'-dimethylbiphenyl-4-yl)carboxylic acid; 3'-Fluoro-2,4'-dimethylbiphenyl-4-carboxylic acid; 2,4'-Dimethyl-3'-fluorobiphenyl-4-carboxylic acid; [1,1'-Biphenyl]-4-carboxylic acid, 3'-fluoro-2,4'-dimethyl-; 3-Fluoro-2,4'-dimethyl-[1,1'-biphenyl]-4-carboxylic acid; 4-Carboxy-3'-fluoro-2,4'-dimethylbiphenyl
EINECS	Contact for details

Quality Control

Our production of 3'-Fluoro-2,4'-Dimethyl-[1,1'-Biphenyl]-4-Carboxylic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. All material is characterized by advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to direct light should be avoided. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.