Description

4-(4-Carboxy-3-Fluorophenyl)-2-Fluorobenzoic Acid is a high-purity fluorinated aromatic dicarboxylic acid derivative, serving as a critical advanced intermediate in modern organic synthesis. Its precise molecular architecture, featuring two carboxylic acid groups and strategically placed fluorine atoms, makes it an invaluable building block for creating complex, functionalized molecules. This compound is primarily sought after by research institutions and pharmaceutical developers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where fluorination is key to enhancing metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas, where the fluorinated biphenyl core is a privileged scaffold.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, leveraging fluorine's ability to improve lipophilicity and environmental stability.
• Ligand & Catalyst Development: Serves as a versatile building block for constructing complex chelating ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer & Material Science: Acts as a monomer or cross-linking agent for producing high-performance polymers, such as polyamides or polyesters, with enhanced thermal and chemical resistance.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating libraries of fluorinated compounds for screening.
• Liquid Crystal & OLED Materials: A potential intermediate for synthesizing fluorinated components used in electronic display technologies due to its rigid, planar structure.

Basic Information

Item	Details
Product Name	4-(4-Carboxy-3-Fluorophenyl)-2-Fluorobenzoic Acid
CAS No.	1261929-07-0
Molecular Formula	C14H8F2O4
Molecular Weight	278.21 g/mol
Synonyms	2-Fluoro-4'-(3-fluoro-4-carboxyphenyl)benzoic acid; 4-(4-Carboxy-3-fluorophenyl)-2-fluorobenzoic acid; 2,2'-Difluoro-4,4'-biphenyldicarboxylic acid; 4,4'-Biphenyldicarboxylic acid, 2,2'-difluoro-; Biphenyl-2,2'-difluoro-4,4'-dicarboxylic acid; [1,1'-Biphenyl]-2,2'-difluoro-4,4'-dicarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 4-(4-Carboxy-3-Fluorophenyl)-2-Fluorobenzoic Acid is manufactured under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specification parameters is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its acidic nature, ensure storage containers are made of compatible materials such as glass or PTFE.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.