Description

2,4'-Difluoro-3'-Methyl-[1,1'-Biphenyl]-4-Carboxylic Acid is a high-purity, multi-substituted biphenyl carboxylic acid derivative, serving as a critical advanced pharmaceutical intermediate. Its precise molecular architecture makes it an essential building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high selectivity. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of novel small molecule drugs, especially non-steroidal anti-inflammatory drugs (NSAIDs) and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging the fluorine atoms for enhanced bioactivity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorine-containing biphenyl cores used in advanced liquid crystal displays (LCDs) and organic electronic materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Stille) to create complex polycyclic structures for material science and catalysis research.
• Chemical Research & Development: Used as a standard or reference compound in analytical method development and structure-activity relationship (SAR) studies.

Basic Information

Product Name	2,4'-Difluoro-3'-Methyl-[1,1'-Biphenyl]-4-Carboxylic Acid
CAS No.	1261926-23-1
Molecular Formula	C14H10F2O2
Molecular Weight	248.23 g/mol
Synonyms	4-(2,4-Difluoro-3-methylphenyl)benzoic acid; [1,1'-Biphenyl]-4-carboxylic acid, 2,4'-difluoro-3'-methyl-; 2,4'-Difluoro-3'-methylbiphenyl-4-carboxylic acid; 3'-Methyl-2,4'-difluoro[1,1'-biphenyl]-4-carboxylic acid; 2-Fluoro-4'-(3-fluoro-2-methylphenyl)benzoic acid; Biphenyl-4-carboxylic acid derivative; DFMBCA
EINECS	Contact for details

Quality Control

Our 2,4'-Difluoro-3'-Methyl-[1,1'-Biphenyl]-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.