Description

3'-Chloro-2,4'-Difluoro-[1,1'-Biphenyl]-4-Carboxylic Acid is a high-purity, multi-substituted biphenyl carboxylic acid derivative, serving as a critical advanced pharmaceutical intermediate. Its precise molecular architecture makes it an essential building block for synthesizing complex active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drugs, particularly in oncology and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging its halogenated biphenyl core.
• Liquid Crystal & OLED Materials: Serves as a precursor for creating specialized organic electronic materials due to its rigid, substituted biphenyl structure.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Negishi) to construct more complex molecular architectures in medicinal chemistry.
• Chemical Research & Development: A valuable reference standard and starting material for academic and industrial R&D exploring new chemical entities.

Basic Information

Product Name	3'-Chloro-2,4'-Difluoro-[1,1'-Biphenyl]-4-Carboxylic Acid
CAS No.	1261922-99-9
Molecular Formula	C13H7ClF2O2
Molecular Weight	268.64 g/mol
Synonyms	3'-Chloro-2,4'-difluorobiphenyl-4-carboxylic acid; 2,4'-Difluoro-3'-chloro-[1,1'-biphenyl]-4-carboxylic acid; 4-Carboxy-3'-chloro-2,4'-difluorobiphenyl; 3-Chloro-2',5-difluoro[1,1'-biphenyl]-4-carboxylic acid; Biphenyl-4-carboxylic acid, 3'-chloro-2,4'-difluoro-; (3'-Chloro-2,4'-difluoro[1,1'-biphenyl]-4-yl)carboxylic acid
EINECS	Contact for details

Quality Control

Our 3'-Chloro-2,4'-Difluoro-[1,1'-Biphenyl]-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.