Description

6-(Difluoromethoxy)-2-Naphthoic Acid is a high-purity, specialized organic building block characterized by its naphthalene core functionalized with a difluoromethoxy group and a carboxylic acid. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique fluorinated structure imparts desirable metabolic stability and bioavailability. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the difluoromethoxy group enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in high-performance liquid crystal displays (LCDs).
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of electron-transport or host materials for OLED devices.
• Advanced Polymer Research: Acts as a monomer or modifying agent for creating specialty polymers with specific thermal and chemical resistance properties.
• Chemical Research & Development: Utilized in academic and industrial R&D for exploring new fluorination chemistry and constructing complex molecular architectures.

Basic Information

Product Name	6-(Difluoromethoxy)-2-Naphthoic Acid
CAS No.	1261884-97-2
Molecular Formula	C₁₂H₈F₂O₃
Molecular Weight	238.19 g/mol
Synonyms	2-Naphthoic acid, 6-(difluoromethoxy)-; 6-(Difluoromethoxy)naphthalene-2-carboxylic acid; 6-Difluoromethoxy-2-naphthoic acid; 2-Carboxy-6-(difluoromethoxy)naphthalene; 1261884-97-2; 6-(Difluoromethoxy)-2-naphthalenecarboxylic acid
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethoxy)-2-Naphthoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical and agrochemical applications. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. The container should be kept tightly sealed when not in use to protect the product from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.