Description

2-Chloro-5-(Trifluoromethoxy)Benzoic Acid is a high-value, multi-functional aromatic carboxylic acid building block distinguished by its unique trifluoromethoxy and chloro substituents. This compound is essential for introducing specific steric, electronic, and lipophilic properties into target molecules, enabling advanced material and pharmaceutical development. It is primarily sought after by R&D chemists and process engineers in the agrochemical, pharmaceutical, and specialty chemical industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a critical precursor in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated components for electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Incorporated as a monomer or additive to create specialty polymers with enhanced chemical resistance, weatherability, and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and esterification/amide formation to construct complex molecular architectures.
• Research & Development: Utilized in academic and industrial labs for exploring new chemical entities and reaction pathways in medicinal and material chemistry.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethoxy)Benzoic Acid
CAS No.	1261836-04-7
Molecular Formula	C8H4ClF3O3
Molecular Weight	240.56 g/mol
Synonyms	2-Chloro-5-(trifluoromethoxy)benzoic acid; Benzoic acid, 2-chloro-5-(trifluoromethoxy)-; 5-(Trifluoromethoxy)-2-chlorobenzoic acid; 2-Chloro-alpha,alpha,α-trifluoro-p-anisic acid; 2-Chloro-5-trifluoromethoxybenzoic acid; 2-Chloro-5-(trifluoromethoxy)benzenecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-5-(Trifluoromethoxy)Benzoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.