Description

4-Fluoro-3-(3-Trifluoromethoxyphenyl)Benzoic Acid is a high-value fluorinated aromatic carboxylic acid derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both fluorine and trifluoromethoxy substituents, is engineered to impart enhanced metabolic stability, lipophilicity, and binding affinity in target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is utilized in the creation of novel active ingredients. Its precise synthesis and high purity are paramount for successful downstream applications and regulatory submissions.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-inflammatory drug candidates.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the fluorine motifs for improved bioactivity and environmental persistence.
• Material Science: Serves as a monomer or functionalizing agent in the production of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular probe or linker due to its aromatic and carboxylic acid functionalities for bioconjugation and labeling studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Fluoro-3-(3-Trifluoromethoxyphenyl)Benzoic Acid
CAS No.	1261831-44-0
Molecular Formula	C14H8F4O3
Molecular Weight	300.21 g/mol
Synonyms	3'-Trifluoromethoxy-4-fluorobiphenyl-3-carboxylic Acid; 4-Fluoro-3-(3-trifluoromethoxyphenyl)benzoic Acid; [1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-3'-(trifluoromethoxy)-; 4-Fluoro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxylic Acid; 4-Fluoro-3-(α,α,α-trifluoro-m-tolyloxy)benzoic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-(3-Trifluoromethoxyphenyl)Benzoic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.