Description

Ethyl 3,6-Difluoro-2-Methoxybenzoate is a high-purity fluorinated aromatic ester building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of fluorine and methoxy substituents, which are crucial for modulating the electronic and steric properties of target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in developing novel active ingredients, particularly where fine-tuning of bioactivity and metabolic stability is required.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of complex drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Serves as a precursor in the development of new-generation herbicides, fungicides, and pesticides, where the difluoro-methoxy benzoate core contributes to enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Material Research: Used in the synthesis of fluorinated aromatic components for electronic materials, contributing to improved dielectric anisotropy and emission properties.
• Advanced Polymer Chemistry: Acts as a monomer or modifying agent for introducing fluorine atoms into polymer backbones to alter thermal stability, chemical resistance, and surface properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions in API (Active Pharmaceutical Ingredient) manufacturing.

Basic Information

Product Name	Ethyl 3,6-Difluoro-2-Methoxybenzoate
CAS No.	1261552-95-7
Molecular Formula	C10H10F2O3
Molecular Weight	216.18 g/mol
Synonyms	Benzoic acid, 3,6-difluoro-2-methoxy-, ethyl ester; Ethyl 3,6-difluoro-2-methoxybenzoate; 2-Methoxy-3,6-difluorobenzoic acid ethyl ester; 3,6-Difluoro-2-methoxybenzoic acid ethyl ester; Ethyl 2-methoxy-3,6-difluorobenzoate
EINECS	Contact for details

Quality Control

Every batch of Ethyl 3,6-Difluoro-2-Methoxybenzoate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing to ensure compliance with stringent purity and identity specifications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, related substances, and other critical parameters as per client requirements. We support development and commercial projects with consistent quality that meets the standards of cGMP and ISO-guided environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.