Description

Methyl 2-Hydroxy-5-(Trifluoromethyl)Benzoate CAS NO 1261478-26-5 is a high-value trifluoromethylated aromatic ester, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, combining a phenolic hydroxyl group with a trifluoromethyl substituent, makes it indispensable for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of anti-inflammatory, antiviral, and central nervous system (CNS) drugs where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl moiety is known to improve efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated organic compounds used in electronic displays and optoelectronic devices.
• Organic Synthesis & Catalysis Research: Employed in academic and industrial R&D labs as a versatile substrate for cross-coupling reactions, esterifications, and the study of novel catalytic processes.
• Fluorinated Polymer Modifier: Acts as a monomer or modifier in the synthesis of specialty polymers to impart unique chemical resistance, thermal stability, and surface properties.

Basic Information

Product Name	Methyl 2-Hydroxy-5-(Trifluoromethyl)Benzoate
CAS No.	1261478-26-5
Molecular Formula	C9H7F3O3
Molecular Weight	220.15 g/mol
Synonyms	Methyl 5-(Trifluoromethyl)salicylate; 2-Hydroxy-5-(trifluoromethyl)benzoic acid methyl ester; Benzoic acid, 2-hydroxy-5-(trifluoromethyl)-, methyl ester; Methyl 2-hydroxy-5-trifluoromethylbenzoate; 5-(Trifluoromethyl)salicylic acid methyl ester; Methyl 5-trifluoromethylsalicylate; Salicylic acid, 5-(trifluoromethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Hydroxy-5-(Trifluoromethyl)Benzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent potential oxidation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.